D-Cycloserine Augmentation of Intermittent Theta Burst Stimulation for Major Depressive Disorder (Cole, Sohn et al., 2022)

D-Cycloserine Augmentation of Intermittent Theta Burst Stimulation for Major Depressive Disorder (Cole, Sohn et al., 2022)

D-Cycloserine Augmentation of Intermittent Theta Burst Stimulation for Major Depressive Disorder (Cole, Sohn et al., 2022)Evan Bartholomeusz
Published on: 09/06/2026

This was a randomized, double-blind, placebo-controlled clinical trial evaluating whether D-cycloserine improves the antidepressant effects of intermittent theta burst stimulation when administered immediately before each TMS session.

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The THREE-D Trial - iTBS Non-Inferior to Standard rTMS for Depression (Blumberger et al. 2018)

The THREE-D Trial - iTBS Non-Inferior to Standard rTMS for Depression (Blumberger et al. 2018)

The THREE-D Trial - iTBS Non-Inferior to Standard rTMS for Depression (Blumberger et al. 2018)Evan Bartholomeusz
Published on: 08/06/2026

The THREE-D trial is the largest randomized controlled trial comparing intermittent theta burst stimulation to standard high-frequency rTMS for major depressive disorder.

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The ONE-D Study — One-Day Theta Burst Stimulation for Treatment-Resistant Depression (Vaughn et al., 2025)

The ONE-D Study — One-Day Theta Burst Stimulation for Treatment-Resistant Depression (Vaughn et al., 2025)

The ONE-D Study — One-Day Theta Burst Stimulation for Treatment-Resistant Depression (Vaughn et al., 2025) Evan Bartholomeusz
Published on: 08/06/2026

The ONE-D study is the first published clinical trial evaluating a complete course of accelerated iTBS delivered in a single day, augmented with D-cycloserine to enhance neuroplasticity throughout treatment.

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The Stanford SAINT Protocol - SNT Trial

The Stanford SAINT Protocol - SNT Trial

The Stanford SAINT Protocol - SNT TrialEvan Bartholomeusz
Published on: 06/06/2026

What this study was - The Stanford Neuromodulation Therapy trial commonly called the SAINT study or SNT trial is the most rigorous published evaluation of accelerated iTBS for treatment-resistant depression.

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